Information about Norprolac (Quinagolide)
Norprolac is a medication containing quinagolide, which is a dopamine agonist used primarily in the treatment of hyperprolactinemia (elevated levels of prolactin in the blood). It works by stimulating dopamine receptors in the brain, which in turn reduces the secretion of prolactin from the pituitary gland. Quinagolide is an effective alternative to other treatments, like bromocriptine, for managing conditions related to prolactin overproduction.
Product Highlights
- Norprolac is used to reduce abnormally high prolactin levels, which can result from conditions like prolactinomas (benign pituitary tumors), hypothyroidism, or certain medications.
- Quinagolide is effective in reducing the size of prolactin-secreting tumors, leading to normalized prolactin levels and improved symptoms.
- In women with infertility caused by high prolactin levels, Norprolac helps restore ovulation and improve chances of conception.
- Quinagolide may be prescribed to treat irregular periods or amenorrhea (absence of menstruation) caused by elevated prolactin levels.
- Quinagolide is used to manage galactorrhea (unwanted milk production), which can occur as a result of excessive prolactin secretion.
Key Ingredient
Key Benefits
- Quinagolide effectively reduces elevated prolactin levels, addressing the underlying cause of many symptoms related to hyperprolactinemia.
- For women with infertility caused by high prolactin levels, Norprolac helps restore normal ovulation, improving the likelihood of conception.
- It can normalize menstrual cycles in women with irregular periods due to prolactin overproduction.
- Quinagolide is a non-ergot dopamine agonist, which may be preferred for some patients because it is associated with a lower risk of certain side effects compared to other dopamine agonists like bromocriptine.
- Norprolac helps stop unwanted milk production in cases of galactorrhea, improving quality of life.
Direction of Use
- The starting dose of Norprolac is typically 0.25 mg once daily in the evening, taken orally with food. The dose may be gradually increased based on patient response and tolerability.
- The dose is often titrated in increments of 0.25 mg every 3–4 weeks, with the usual maintenance dose being 0.5 mg to 1 mg per day.
- The maximum recommended dose is 1 mg per day.
- Norprolac should be taken once daily, preferably in the evening, with food to reduce the risk of gastrointestinal side effects.
- If a dose is missed, take it as soon as you remember, unless it's almost time for the next dose. In that case, skip the missed dose and resume your usual dosing schedule. Do not take a double dose.
Safety Concerns
- Quinagolide may cause dizziness, lightheadedness, or fainting, especially when standing up quickly, due to its potential to lower blood pressure. It is important to rise slowly from a sitting or lying position to prevent dizziness.
- Some patients may experience nausea, vomiting, or abdominal discomfort when starting the medication. Taking the medication with food might help reduce these side effects.
- Dopamine agonists can cause psychiatric side effects such as hallucinations, confusion, or mood changes. Patients should be closely monitored for any changes in mental health or behavior.
- Quinagolide may cause tiredness or sleepiness, particularly during the first few weeks of treatment.
- Although quinagolide is used to treat hormonal imbalances, it may, in rare cases, affect other hormone levels. Regular monitoring of prolactin and other relevant hormones is important.
- The safety of quinagolide during pregnancy has not been well studied. It should only be used during pregnancy if the potential benefits outweigh the possible risks to the fetus. Women should discuss potential risks with their healthcare provider if pregnant or planning to become pregnant.
Avoid Norprolac (Quinagolide) If
- Avoid Norprolac if you have a known allergy to quinagolide or any of the ingredients in the medication.
- Norprolac should not be used in patients with severe liver disease, as liver function affects the metabolism of quinagolide.
- Patients with uncontrolled low blood pressure or severe cardiac conditions should avoid quinagolide, as it may exacerbate these issues.
- Quinagolide should not be used during pregnancy, especially during the first trimester, unless the potential benefits outweigh the risks. It is essential to discuss the risks with a healthcare provider before use.
- Quinagolide may pass into breast milk and is generally not recommended for use while breastfeeding. A healthcare provider should be consulted to discuss alternative options.
- Quinagolide should be used with caution in patients with a history of psychiatric disorders such as schizophrenia or psychosis, as dopamine agonists can potentially worsen these conditions.
