Information about Trientine (Syprine)
Trientine (Syprine) is an oral medication used primarily in the treatment of Wilson's disease, a rare genetic disorder in which excessive copper builds up in the body. Trientine is a copper chelator, meaning it binds to copper in the bloodstream, allowing it to be excreted from the body, helping to prevent copper toxicity.
Product Highlights
- Used in the treatment of Wilson’s disease to reduce copper accumulation in the body by increasing copper excretion.
- In certain cases of copper toxicity or overload, Trientine may also be used, particularly in patients with difficulty tolerating other therapies.
Key Ingredient
Key Benefits
- Trientine helps prevent the accumulation of copper in the liver and other vital organs, which is crucial in managing Wilson's disease.
- By reducing copper levels, Trientine can help improve liver function and reduce the risk of liver damage associated with Wilson's disease.
- In patients with neurological symptoms due to Wilson's disease, Trientine can help reduce the copper-induced damage to the brain and central nervous system.
- Compared to penicillamine, another copper chelator, Trientine may be better tolerated, particularly in patients who experience adverse reactions to penicillamine.
Direction of Use
- The exact dosage of Trientine (Syprine) is determined by the patient's doctor based on the severity of the condition and individual response to treatment. It is typically taken in divided doses, usually 1–2 times daily.
- Trientine capsules should be taken on an empty stomach, preferably 1 hour before meals or 2 hours after meals, to enhance absorption.
- The absorption of Trientine can be reduced if taken with iron supplements, multivitamins, or food containing high levels of copper or iron. Therefore, it is recommended to separate Trientine dosing from these substances.
Safety Concerns
- Common side effects include nausea, vomiting, and stomach discomfort. These are typically less severe when the medication is taken with a sufficient gap from meals.
- Trientine can cause low levels of white blood cells (leukopenia), platelets (thrombocytopenia), and red blood cells (anemia) in some patients, which requires regular blood monitoring.
- Long-term use of Trientine can sometimes affect kidney function. Regular kidney function tests should be done during treatment.
- Though rare, some individuals may experience allergic reactions such as rash, fever, or difficulty breathing.
- Prolonged treatment with Trientine can lead to a deficiency of copper, which is essential for various bodily functions. Symptoms of copper deficiency may include fatigue, weakness, and neurological symptoms.
Avoid Trientine (Syprine) If
- You are allergic to Trientine or any of its ingredients.
- You have severe kidney or liver problems, as Trientine may exacerbate these conditions in some individuals.
- You are pregnant or breastfeeding, unless prescribed by a healthcare provider who assesses that the benefits outweigh the potential risks.
- You have a history of blood disorders, as Trientine can affect blood cell counts, requiring caution and regular monitoring.
- You are taking iron supplements or medications containing copper, as these can interact with Trientine, reducing its effectiveness.
