Information about Berinert (C1 esterase Inhibitor)
Berinert is a medication used primarily for the treatment and management of hereditary angioedema (HAE), a rare genetic condition characterized by recurrent episodes of severe swelling. This medication works by replacing the deficient or malfunctioning C1 esterase inhibitor, which helps regulate the complement and contact systems in the blood, thus preventing excessive swelling.
Product Highlights
- Treatment of acute attacks of hereditary angioedema (HAE) and prevention of such attacks.
- Available in form of Intravenous (IV) infusion.
- C1 esterase inhibitor active ingredient of berinert is a protein derived from human plasma. It works to control the complement and contact systems of blood, which are involved in inflammatory responses.
Key Ingredient
Key Benefits
- Effectively controls and mitigates swelling during acute HAE attacks.
- Can be used prophylactically to prevent HAE attacks in individuals with frequent episodes.
- Helps manage symptoms and reduce the frequency of attacks, thus improving daily functioning and quality of life.
Direction of Use
- The dosage and frequency of administration are determined by a healthcare provider based on the individual’s needs and response to the treatment.
- Normally recommended dose is 60 IU per kg body weight twice weekly (every 3–4 days).
Safety Concerns
- Monitor for signs of allergic reactions such as rash, itching, or difficulty breathing.
- Because it is derived from human plasma, there is a slight risk of transmission of infectious agents, though the product is screened and treated to reduce this risk.
- Symptoms of thromboembolism include pain, swelling, redness, and warmth in limbs or sudden shortness of breath.
Avoid Berinert (C1 esterase Inhibitor) If
- You have a known allergy to C1 esterase inhibitor or any of its components.
- You have a history of severe allergic reactions or have specific contraindications advised by your healthcare provider.
- If you have active HIV or hepatitis infections, consult your healthcare provider, as specific precautions may be needed.
