Information about Renagel (Sevelamer)
Renagel is the brand name for Sevelamer, a phosphate binder used to control high levels of phosphate in the blood (hyperphosphatemia) in patients with chronic kidney disease (CKD) who are on dialysis. It works by binding to phosphate in the gastrointestinal tract, stopping its absorption into the bloodstream.
Product Highlights
- Hyperphosphatemia in patients with chronic kidney disease (CKD) who are on dialysis (hemodialysis or peritoneal dialysis).
- It helps maintain phosphate levels within a normal range to prevent complications such as cardiovascular problems, bone mineral disorders, and other issues associated with high phosphate levels.
Key Ingredient
Key Benefits
- Sevelamer binds to phosphate in the intestines, inhibiting its absorption and helping to lower phosphate levels in the blood.
- Helps avoid the complications of hyperphosphatemia, such as cardiovascular diseases, bone disease, and calcification of soft tissues.
- Unlike some other phosphate binders, Renagel does not contribute to calcium or aluminum buildup, which can cause problems like hypercalcemia and aluminum toxicity.
- By controlling phosphate levels, Renagel contributes to better overall health in patients with CKD, reducing the need for additional treatments related to phosphate imbalance.
Direction of Use
- Renagel (Sevelamer) should be taken with meals, as it works by binding to the phosphate in food.
- The tablets should be taken whole and not crushed or chewed.
- The dosage and frequency depend on the patient's phosphate levels, dialysis regimen, and overall health condition.
- Patients should follow the prescribed dose from their healthcare provider and may require regular blood tests to monitor phosphate levels.
Safety Concerns
- The most common side effects are nausea, vomiting, diarrhea, constipation, and abdominal discomfort.
- Sevelamer can cause gastrointestinal issues, especially in those with existing bowel problems.
- Sevelamer may interfere with the absorption of certain drugs, including some antibiotics, levothyroxine, and mycophenolate mofetil.
- Long-term use should be monitored to avoid imbalances in electrolytes like calcium and magnesium.
- Not suitable for use in people with bowel obstructions.
Avoid Renagel (Sevelamer) If
- You have a bowel obstruction or a history of severe gastrointestinal problems.
- You are allergic to Sevelamer or any of the components of the product.
- You are not on dialysis or do not have chronic kidney disease (CKD), as this medication is specifically for managing phosphate levels in dialysis patients.
- You are pregnant or breastfeeding, unless advised by a healthcare professional, as the safety during pregnancy and lactation is not fully established. Always consult with a healthcare provider before starting Renagel.
