Zemplar (Paricalcitol)

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Brand Name : Zemplar

Marketing Authorization Holder : AbbVie

Prescription Required

 
 
No Generic Medicine available for this medicine.

Product Details

Zemplar

Information about Zemplar (Paricalcitol)

Zemplar, also known by its generic name Paricalcitol, is a synthetic vitamin D analog used primarily in the treatment of secondary hyperparathyroidism, which often occurs in patients with chronic kidney disease (CKD). It works by binding to vitamin D receptors in the body to regulate parathyroid hormone (PTH) levels and calcium metabolism, helping to control calcium and phosphate balance.

Product Highlights

  • Zemplar is primarily indicated for the treatment of secondary hyperparathyroidism in patients with CKD. This condition is characterized by high levels of parathyroid hormone (PTH) due to disturbed calcium and phosphate balance.
  • It is used to control PTH levels, which helps maintain proper calcium balance and reduce the risk of bone and cardiovascular complications in CKD patients.

Key Ingredient

  • Paricalcitol

Key Benefits

  • By targeting the parathyroid glands, Paricalcitol helps lower elevated PTH levels, which can improve calcium and phosphate balance in the body.
  • Unlike other forms of vitamin D, Paricalcitol has a lower risk of causing elevated calcium levels in the blood, making it a safer option for CKD patients.
  • Helps manage calcium and phosphate metabolism, which is crucial for maintaining bone strength and preventing bone-related complications in CKD patients.
  • Zemplar is available in both oral and injectable forms, allowing for tailored treatment plans depending on the patient’s specific needs.

Direction of Use

  • Zemplar is usually taken once daily with or without food. The dosage is based on the patient’s condition, typically determined by a healthcare provider.
  • Paricalcitol can also be administered as an intravenous injection, often used in a clinical setting. The dosing schedule is generally managed by a healthcare provider.

Safety Concerns

  • While Zemplar is designed to prevent hypercalcemia, there is still a risk of calcium levels becoming too high. Regular monitoring of calcium and phosphate levels is recommended.
  • As Paricalcitol regulates calcium and phosphate balance, improper dosing may lead to imbalances that can cause complications such as soft tissue calcification or bone disease.
  • Patients with severe kidney impairment may need careful dosing adjustments. Monitoring kidney function is important during treatment.
  • Paricalcitol may interact with certain medications, including calcium-based phosphate binders and other vitamin D analogs. It's important to inform healthcare providers of any other medications being taken.

Avoid Zemplar (Paricalcitol) If

  • You have hypercalcemia (high levels of calcium in the blood) or hyperphosphatemia (high phosphate levels).
  • You have a history of calcium metabolism disorders or vitamin D toxicity.
  • You are allergic to Paricalcitol or any of the ingredients in Zemplar.
  • You have severe liver dysfunction or any condition affecting your liver’s ability to process medications.
  • You are pregnant or breastfeeding, unless directed by a healthcare provider, as the safety of Zemplar during pregnancy or breastfeeding has not been fully established.


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