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Information about Zortress (Everolimus)
Zortress is a medication that contains Everolimus as its active ingredient. It is an immunosuppressant drug that works by inhibiting a specific protein called mTOR (mechanistic target of rapamycin), which plays a critical role in cell growth, proliferation, and survival. Zortress is mainly used in patients who have undergone organ transplants to prevent organ rejection, as well as in the treatment of certain types of cancer.
Product Highlights
- Zortress is primarily used for:
- In kidney and liver transplant recipients, Zortress helps prevent the body's immune system from attacking the transplanted organ.
- It is used as part of cancer therapy for various types of cancers, such as renal cell carcinoma (a type of kidney cancer), and sometimes in certain breast cancers or neuroendocrine tumors.
- Zortress is also used to treat this rare lung disease, which is characterized by the abnormal growth of smooth muscle cells in the lungs.
Key Ingredient
Key Benefits
- Zortress reduces the risk of organ rejection after kidney and liver transplants.
- It is effective in treating certain cancers by slowing or stopping the growth of cancer cells.
- Zortress can slow the progression of LAM, improving lung function and reducing complications associated with the disease.
- It is taken as an oral tablet, making it more convenient compared to injectable immunosuppressants.
Direction of Use
- The dosage of Zortress will be determined by a healthcare provider and is usually adjusted based on the specific condition being treated.
- For organ transplant recipients, it’s typically taken in combination with other immunosuppressants.
- For cancer treatments, doses are carefully calculated based on the type and stage of cancer.
- Zortress should be taken by mouth with or without food. It is important to take the medication at the same time each day for consistent blood levels.
- Do not crush, chew, or break the tablets. Swallow them whole with a glass of water.
- Regular blood tests are required to monitor drug levels and ensure effectiveness while preventing side effects.
Safety Concerns
- Common side effects include mouth sores, fever, fatigue, diarrhea, nausea, and increased risk of infections. Serious side effects may include kidney problems, lung issues, or liver problems.
- Since Zortress suppresses the immune system, it can increase the risk of infections, including bacterial, viral, and fungal infections.
- Long-term use of Zortress may increase the risk of certain cancers due to immune suppression.
- Zortress can affect kidney and liver function, so regular monitoring of these organs is essential during treatment.
Avoid Zortress (Everolimus) If
- You have a known allergy to Everolimus or any of the components of Zortress.
- You are pregnant or planning to become pregnant, as Zortress can harm the fetus.
- You are breastfeeding, as Everolimus may pass into breast milk and harm a nursing infant.
- You have severe liver or kidney impairment, as the drug may worsen these conditions.
- You are taking medications that interact with Everolimus, such as strong CYP3A4 inhibitors or inducers, which may affect how the drug works.
- You have an active infection or have recently received a vaccination with a live vaccine.
