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Information about Hepsera
Hepsera is an antiviral medication that contains adefovir dipivoxil, primarily used for the treatment of chronic hepatitis B virus (HBV) infection. It functions by blocking viral replication, which helps lower the viral load in the body.
Product Highlights
Indicated for the treatment of chronic hepatitis B in adults with evidence of active viral replication and liver inflammation.
Key Ingredient
Adefovir Dipivoxil
Key Benefits
Helps reduce HBV replication, leading to improved liver function and lower risk of complications.
May decrease the likelihood of liver damage and progression to cirrhosis or liver cancer.
Generally well-tolerated with a manageable side effect profile compared to some other antiviral therapies.
Direction of Use
The typical dose for adults is 10 mg once daily, taken at the same time each day.
Can be taken with or without food; swallowing the tablet whole with water is recommended.
Regular follow-up appointments are necessary to monitor liver function and viral load.
Dose adjustment in renal impairment for adults
Creatinine Clearance (mL/min)a
Greater than or equal to 50
30–49
10–29
Hemodialysis Patients
Recommended dose and dosing interval
10 mg every 24 hours
10 mg every 48 hours
10 mg every 72 hours
10 mg every 7 days following dialysis
Patients with creatinine clearance of less than 10 mL per minute who are not on hemodialysis.
Safety Concerns
May include headache, abdominal pain, nausea, and diarrhea.
Can cause kidney problems; renal function should be monitored, especially in patients with pre-existing conditions.
There is a risk of lactic acidosis, particularly in patients with underlying liver disease.
Avoid Hepsera (Adefovir) If
Known allergy to adefovir or any of its components.
Contraindicated in patients with significant renal dysfunction; alternative treatments should be considered.
Caution is advised; consult a healthcare provider for recommendations in these situations.
Avoid in patients with severe liver disease or those at risk of liver decompensation.
