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Non-english packaging is often present for European medicines- English label and English insert included. Plan in advance - allow us 7 days to ship this brand name medicine.
According to the European Medicines Agency, brand name Sovaldi originating from Europe is manufactured at the following site(s):
Gilead Sciences Ireland UC
IDA Business & Technology Park
Carrigtohill
County Cork
Ireland
Information about Sovaldi (Sofosbuvir)
Sovaldi (Sofosbuvir) is an antiviral medication used primarily for the treatment of chronic hepatitis C, a liver disease caused by the hepatitis C virus (HCV). It is a direct-acting antiviral (DAA) that works by inhibiting the NS5B polymerase, a key enzyme necessary for the replication of the HCV virus.
Product Highlights
- Sovaldi is mainly prescribed for the treatment of chronic HCV infection in adults, typically in combination with other antiviral agents such as ribavirin, peginterferon, or other direct-acting antivirals like ledipasvir (in Harvoni).
- Sovaldi is effective against various genotypes of hepatitis C, but the specific combination and duration of therapy depend on the viral genotype and the presence of any liver damage (e.g., cirrhosis).
Key Ingredient
Key Benefits
- Sofosbuvir, in combination with other antiviral agents, has shown high cure rates for hepatitis C, particularly for patients with genotypes 1 and 2.
- Treatment with Sovaldi often requires only 8-12 weeks of therapy, depending on the combination therapy used.
- Sofosbuvir has relatively fewer and milder side effects compared to older hepatitis C medications like interferon-based treatments.
- Successful treatment with Sovaldi helps prevent further liver damage and may reverse some liver complications caused by hepatitis C, including cirrhosis and liver cancer.
Direction of Use
- Usually, one 400 mg tablet of Sovaldi is taken once a day, with or without food.
- Sovaldi is generally prescribed in combination with other medications, such as ledipasvir (as in Harvoni), ribavirin, or peginterferon.
- The treatment duration usually varies from 8 to 24 weeks depending on the hepatitis C genotype, viral load, and the presence of cirrhosis.
- Patients need regular blood tests to monitor liver function and the effectiveness of the treatment.
Safety Concerns
- Sofosbuvir may interact with other medications, such as certain anticonvulsants, HIV medications, and other antiviral drugs, which can affect its efficacy and safety.
- Frequent side effects may include fatigue, headaches, nausea, and difficulty sleeping. Serious side effects, although rare, can include severe liver problems, especially in patients with advanced cirrhosis.
- Special caution is advised in patients with severe liver impairment, those who are pregnant, or breastfeeding. Sofosbuvir is not recommended for use in children under 3 years of age.
Avoid Sovaldi (Sofosbuvir) If
- If you are allergic to Sofosbuvir or any component of the medication, you should avoid using it.
- Sovaldi should not be used by individuals with decompensated cirrhosis (severe liver damage), unless prescribed as part of a combination therapy for advanced cases.
- Patients with co-infection of HIV and HCV should use caution and may need adjusted dosing or monitoring.
- Sofosbuvir should not be used during pregnancy unless there is a clear medical necessity. Women of childbearing age should avoid becoming pregnant while on therapy, as some combinations of Sofosbuvir can be harmful to a developing fetus.
- Avoid using Sofosbuvir with certain medications, such as those that interact with its metabolism, including drugs that can alter liver enzyme function (e.g., rifampin, St. John’s Wort).
