Tyzeka (Telbivudine)

In the United Kingdom, Tyzeka is marketed by the name Sebivo. Both brands are manufactured by Novartis.

Prescription Tyzeka contains the active ingredient telbivudine, an antiviral medicine used to treat adults with chronic hepatitis B. Tyzeka is prescribed when you cannot take other available antiviral treatments. Tyzeka blocks the growth of the virus that causes hepatitis, reducing the levels of the virus in your body, resulting in improved liver function and less liver damage.

Tyzeka 600mg tablets are taken once per day with or without food at the same time each day. Always take Tyzeka exactly as prescribed by your physician. Do not stop taking Tyzeka without consulting your physician, even if you are feeling better. Tyzeka is given over the long term, usually months or years. Your physician will monitor your condition to ensure that Tyzeka is working properly.

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Information about Tyzeka (Telbivudine)

Tyzeka (Telbivudine) is an antiviral drug that works by inhibiting the replication of the hepatitis B virus (HBV) in the body. It is a nucleoside analogue, which means it mimics the building blocks of DNA, preventing the virus from multiplying. This helps control the virus, reduce liver damage, and prevent the progression of hepatitis B.

Product Highlights

• Tyzeka is indicated for the treatment of chronic hepatitis B infection in adults and pediatric patients (aged 16 years and older) with evidence of active viral replication and liver inflammation.
• It is generally prescribed when the patient’s condition is not adequately controlled with other treatments or if they are newly diagnosed.

Key Ingredient

• Telbivudine

Key Benefits

• Tyzeka effectively lowers the level of hepatitis B virus in the bloodstream, helping to control the infection.
• By suppressing the virus, it helps to reduce liver damage, inflammation, and the risk of liver cirrhosis or liver cancer.
• Tyzeka is taken as a once-daily oral tablet, making it easy for patients to incorporate into their daily routine.
• Long-term use of Tyzeka has been shown to improve liver function by reducing viral load and preventing further liver damage.

Direction of Use

• The usual dose of Tyzeka is 600 mg once daily, taken orally.
• It can be taken with or without food. The tablet should be taken whole and not crushed or chewed. 
• Tyzeka is often prescribed as part of a long-term treatment regimen, and patients should continue taking it as prescribed, even if they feel well, to effectively control the infection.

Safety Concerns

• Telbivudine can, in rare cases, lead to a buildup of lactic acid in the blood, which can be life-threatening. Regular monitoring is recommended, especially for patients with preexisting health conditions like kidney disease.
• Discontinuation of Tyzeka, particularly without proper medical supervision, can lead to a sudden worsening of hepatitis B symptoms (referred to as a flare-up).
• Monitoring liver function is important during treatment, as there could be liver-related side effects or worsening of liver disease in some cases.
• Telbivudine is eliminated through the kidneys, so it should be used with caution in patients with impaired kidney function. Regular kidney function tests are recommended.
• Muscle pain, tenderness, and weakness (myopathy) are possible side effects of Tyzeka, and should be reported to a doctor if they occur.

Avoid Tyzeka (Telbivudine) If

• If you have a known allergy to Tyzeka or any of its components, it should be avoided.
• Tyzeka should not be used in patients with severe kidney impairment because the drug is excreted through the kidneys and may accumulate, leading to increased risk of side effects.
• The safety of Tyzeka during pregnancy or breastfeeding has not been fully established, so it should only be used if absolutely necessary and under the guidance of a healthcare provider.
• If you are taking other medications that could interact with Tyzeka, particularly those that affect kidney function or liver function, your healthcare provider may need to adjust your treatment plan or monitor you closely.