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Prescription Pradaxa contains dabigatran, an anticoagulant (blood thinner) that blocks blood clot formation by inhibiting thrombin, the central clotting agent in the blood. By attaching to thrombin, Pradaxa prevents thrombin from producing the clot in the body.
Adults are prescribed Pradaxa for the prevention of blood clot formation in the brain, veins or other blood vessels and to treat clots in the legs and lungs. Pradaxa is prescribed (1) after knee and hip surgery, (2) in people with nonvalvular atrial fibrillation (and one or more other risk factor), (3) in people with existing blood clots in legs and lungs (DVT) and prevention of these clots.
Pradaxa was the first FDA approved warfarin alternative for reduction of stroke in atrial fibrillation not caused by problem with heart valve. Pradaxa reduces stroke risk better than warfarin in those with atrial fibrillation not caused by valve problems in the heart.
Pradaxa should be taken as prescribed by the doctor as there are many different treatment plans depending on the patients condition and the treatment goals. Do not stop Pradaxa unless advised to do so by your physician. One such time to stop treatment temporarily is prior to any scheduled surgery, so advise your healthcare team of all the medicines you take prior to any surgery.
Pradaxa treatment does not require regular blood tests. Pradaxa does not require any special dietary restriction.
Pradaxa can be taken with or without food, swallowed whole with water and is not to be crushed, chewed or emptied from the capsule.
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Information about Pradaxa (Dabigatran)
Pradaxa (generic name: Dabigatran) is an oral anticoagulant (blood thinner) used to reduce the risk of stroke and blood clots in certain conditions. It belongs to a class of drugs called direct thrombin inhibitors and works by directly inhibiting the enzyme thrombin, which plays a key role in blood clot formation.
Product Highlights
- Pradaxa is used to reduce the risk of stroke and blood clots in individuals with non-valvular atrial fibrillation (AFib), a condition where the heart beats irregularly and increases the likelihood of clot formation.
- Pradaxa is used to treat and prevent blood clots in the legs (DVT) and lungs (PE), conditions that can be life-threatening if not managed appropriately.
- Pradaxa is used to prevent the formation of blood clots following knee or hip replacement surgery.
Key Ingredient
Key Benefits
- Pradaxa significantly lowers the risk of stroke and systemic embolism in patients with atrial fibrillation, making it a critical medication for patients with this condition.
- Unlike warfarin and other blood thinners, Pradaxa generally does not require regular blood tests to monitor its effect, which simplifies management for patients.
- Pradaxa is effective in both the treatment and prevention of deep vein thrombosis and pulmonary embolism, preventing the dangerous consequences of these conditions.
- Pradaxa is taken orally, typically twice a day, and does not require frequent adjustments based on diet or other medications, unlike some other anticoagulants.
Directions for Use
- Pradaxa should be taken exactly as prescribed. The usual dose for stroke prevention in atrial fibrillation is 150 mg, administered twice a day. For DVT or PE treatment, it may be started with a higher initial dose.
- Pradaxa can be taken with or without food. Taking it with food is recommended to help minimize the risk of gastrointestinal discomfort.
- The capsules should be taken whole and not broken, crushed, or chewed.
- If you miss a dose, take it as soon as you remember, unless it's nearly time for your next dose. Do not take two doses to make up for a missed one.
Safety Concerns
- As an anticoagulant, Pradaxa increases the risk of bleeding, which can be severe or even life-threatening. Patients should be monitored for signs of excessive bleeding, such as unusual bruising, nosebleeds, or blood in the urine or stool.
- Pradaxa is primarily eliminated through the kidneys, so impaired kidney function can increase the risk of side effects. Kidney function should be monitored regularly, especially in elderly patients or those with pre-existing kidney conditions.
- Common side effects include stomach upset, indigestion, and abdominal pain. These are generally mild but should be discussed with a healthcare provider if persistent or severe.
- In the case of major bleeding, a specific reversal agent called Idarucizumab can be used to neutralize the effects of dabigatran.
- Stopping Pradaxa suddenly may increase the risk of blood clots. Always speak with your doctor before stopping the medication.
Avoid Pradaxa (Dabigatran) If
- Do not take Pradaxa if you have active bleeding, such as from a peptic ulcer, brain hemorrhage, or other serious bleeding conditions.
- Pradaxa should be avoided in patients with severe renal impairment (CrCl < 15 mL/min) as it can accumulate in the body and increase the risk of bleeding.
- Do not take Pradaxa if you are allergic to dabigatran or any of its ingredients.
- Pradaxa should be avoided during pregnancy unless the potential benefits outweigh the risks, as it is classified as Category C for pregnancy.