Akynzeo (Netupitant / Palonosetron)

Save over 65% on brand name Akynzeo.

Akynzeo in Europe is manufactured by: Helsinn Birex Pharmaceuticals Ltd. Damastown Mulhuddart Dublin 15 Ireland

Information About AKYNZEO (Netupitant / Palonosetron):

AKYNZEO capsules are indicated in combination with dexamethasone in adults for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of cancer chemotherapy, including highly emetogenic chemotherapy.

AKYNZEO injection formulations, when used together with dexamethasone, are specifically intended to prevent nausea and vomiting in adult patients undergoing highly emetogenic chemotherapy, both immediately after treatment (acute phase) and up to several days afterward (delayed phase).

Product Highlights

• AKYNZEO come 2 forms in capsules and other is solution for injection.
• AKYNZEO is a medication that combines two active ingredients, netupitant and palonosetron, to prevent nausea and vomiting caused by chemotherapy. 
• It is particularly effective in preventing both acute and delayed phases of chemotherapy-induced nausea and vomiting (CINV).

Key Ingredients:

• Netupitant
• Palonosetron

Key Benefits:

• AKYNZEO provides effective prevention of nausea and vomiting in both the acute phase (within 24 hours after chemotherapy) and the delayed phase (25-120 hours after chemotherapy).
• It is administered as a single capsule, simplifying the dosing regimen compared to taking multiple medications separately.
• The combination of netupitant and palonosetron provides prolonged relief compared to single-agent therapies.

Direction For Use:

• AKYNZEO Capsule Dose:

               AKYNZEO is usually taken orally as a single capsule, typically 1 hour before the start of chemotherapy.

               It can be taken with or without food.

• AKYNZEO Injection Dose:

              This should be given 30 minutes before the start of chemotherapy.

Safety Concerns:

• Common side effects may include headache, constipation, fatigue, and dizziness.
• Rare but serious side effects can include allergic reactions, serotonin syndrome (particularly if used with other serotonergic medications), and QT prolongation (especially in patients with certain cardiac conditions or taking other medications that prolong the QT interval).

Avoid Taking if AKYNZEO (Netupitant / Palonosetron):

• Do not take AKYNZEO if you are allergic to netupitant, palonosetron, or any other ingredients in the medication.
• Avoid taking AKYNZEO if you are currently using medications that are strong CYP3A4 inhibitors (such as ketoconazole, clarithromycin) or strong CYP3A4 inducers (such as rifampicin, carbamazepine), as these can affect the metabolism of netupitant.