Restless Leg Syndrome (RLS) is a neurological disorder characterized by an irresistible urge to move the legs, often accompanied by uncomfortable sensations. These symptoms typically worsen during periods of rest or inactivity, making it difficult for individuals to relax or sleep, which can lead to significant disruptions in daily life. While the exact cause of RLS remains unclear, it is believed to involve a combination of genetic, environmental, and neurological factors. Fortunately, a range of treatment options is available to help manage the symptoms of RLS. Medications such as dopaminergic agents, anticonvulsants, and opioids can offer relief, while lifestyle changes and non-pharmacological therapies may also play a supportive role. In this overview, we will explore the various medications used to treat Restless Leg Syndrome, their mechanisms of action, and how they can help improve the quality of life for those affected by this condition.